Momentum Trends in Presentation of Disease Associated with M. hyopneumoniae Monte B. McCaw DVM PhD Farm Animal Health and Resource Management Dept. NCSU College of Vet. Med.
Slide 2M. hyo history Pre 1990 "inconsequential" in US no M hyo immunization no M hyo focused on abc programs uncommon to see clinical infection flare-ups SPF groups part as App facilitator
Slide 3M. hyo history Late 1980's - 1990's emotional "outlook change" in hoard raising administration presentation of PRRSv and resulting scourges development of PRDC M hyo focal part
Slide 4Presentation Overview Swine Industry Changes PRRSv Impact on Disease Antibiotic Therapy Challenges
Slide 5Swine Industry Changes Continuous Pig-Flow Rearing different age bunches building or site never cleaned/purified endemic ailment demonstrate Day Care/School-kid display
Slide 11Swine Industry Changes All In - All Out (AIAO) Pig-stream Rearing single age gathering room/building/site set at same time purged totally cleaned and sterilized
Slide 17Swine Industry Changes AIAO Pig-stream Rearing End old-to-youthful transmission diminishing contact/introduction Must be immaculate to be successful!!?? Guileless populace if effective Epidemic Disease Model???
Slide 18Swine Industry Changes Site level ailment control 1 site creation "farrow to complete" (Farrowing)(Nursery)(grow-Finish)
Slide 20Swine Industry Changes Site level infection control 3 site generation additionally diminish old to youthful transmission hazard Farrowing (Breeding Herd) Nursery develop Finish
Slide 21Swine Industry Changes 3 site generation goals Eliminate microbes vertical transmission anti-infection drug during childbirth early weaning (3 to 7 days) partition to various site little gathering sizes
Slide 22Swine Industry Changes 3 site creation adjustment unmedicated before weaning weaned at standard 3 weeks division to various site VERY LARGE gathering sizes low rate vertical transmission critical???
Slide 23Swine Industry Changes 3 site creation adjustment UNSUCCESSFUL in forestalling malady transmission and misfortunes Successful in diminishing illness misfortunes of the past May have encouraged rise new (deferred) ailment disorders
Slide 26Swine Industry Changes 3 site generation adjustment SINGLE SITE wellspring of pigs ESSENTIAL for ailment control PRV, TGE, pneumonia PRRSv various "strains", diverse status infection dissemination between crowds
Slide 27PRRSv Impact on Disease PRRS Clinical signs fetus removal, stillbirths, mummies high preweaning mortality high nursery ailment and mortalilty later observe finisher pig pneumonia M hyo focal part PRDC
Slide 28PRRSv Impact on Disease PRRS sickness and mortality frequently from optional bacterial ailments
Slide 29PRRSv Impact on Disease PRRSv contaminations are immunosupressive in utero contamination thymic decay lymph hub extension interstitial pneumonia auxiliary bacterial sores
Slide 32PRRSv Impact on Disease PRRSv immunosupressive Peripheral Blood Mononuclear Lymphocyte CD4/CD8 proportion inversion
Slide 33IU tainted pig PBMC Cytokines
Slide 34IU contaminated pig PBMC Cytokines
Slide 35IU contaminated pig PBMC Cytokines
Slide 36IU tainted pig PBMC Cytokines
Slide 37PRRSv Impact on Disease In utero PRRSv disease affect immunosuppressed VERY powerless 2 o bacterial disease long haul viremic Typhoid Marys MUST CONTROL SOW PRRSv disease to control finisher PRRS
Slide 39PRRSv Impact on Disease I = pc y/N I = rate p = exchange likelihood c = contact y = amount of irresistible pigs N = assemble estimate
Slide 40PRRSv Impact on Disease
Slide 41PRRSv Impact on Disease Horizontal nursery/finisher spread basic finisher ailment M hyo PRDC (SIV, PRCV, PCV2/PMWS ) hard to reproduce tentatively extreme PRRSv strain Halbur/Thacker dexamethazone improved Zimmerman
Slide 42PRRSv Impact on Disease Horizontal nursery/finisher spread conceivable field contributing components expansive populaces social collaboration variables poorer ventilation control relentless bacterial/infection presentation traded off/focused on pigs on passage
Slide 43Antibiotic Therapy Challenges PRRS (nursery/finisher) Increased measure of finisher ailment??? Seems expanded utilization of anti-infection agents
Slide 44Antibiotic Therapy Challenges PRRS (nursery/finisher) grumbling anti-toxins "aren't working" must utilize any longer term pull back anti-microbials in dissatisfaction
Slide 45Antibiotic Therapy Challenges PRRS-related anti-infection "disappointment" PRRSv taints macrophages PAM, PIM diminished phagocytic action diminished murdering capacity Impaired bacterial leeway systems!!
Slide 46Antibiotic Therapy Challenges PRRS-related anti-infection "disappointment" Uncertian impacts upon PMN enrollment and bacterial slaughtering in vivo
Slide 47Antibiotic Therapy Challenges PRRS-related anti-infection "disappointment" Antibiotic viability decreased by powerlessness of pig's resistant framework to successfully clear microbes anti-microbials alone not murder all microscopic organisms in vivo
Slide 48Summary current anti-infection utilize challenges in swine Dramatically changed creature "stream" designs that make almost credulous populaces and scourge sickness conditions
Slide 49Summary present day anti-infection utilize challenges in swine Immunocompromising viral contaminations regular in nursery and completing swine PRRSv M hyo SIV PCR 2
Slide 50Summary present day anti-infection utilize challenges in swine Antibiotics seem less compelling against bacterial ailments, for example, M hyopneumoniae amid coinfections including immunosupressive infections like PRRSv and perhaps PCV2
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