Urinary Path Review

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Slide 1

Urinary Path Review

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Normal Prostate Two parts of the prostate: Glands Stroma Glands have 2 sort of cells: Basal luminal

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Normal prostate Note the two cell layers and constant layer of basal cells. The nearness of basal cells demonstrates generosity

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What markers and recoloring do the basal cells have?

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Basal cells recolor with high atomic weight cytokeratin, PSA - and PAP - What about the luminal cells?

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Luminal cells are PSA + and PAP+

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Which zone of the prostate is the territory of hyperplasia?

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Transitional Zone, periurethral In which zone do most carcinomas emerge?

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Peripheral Zone Makes up the main part of the organ Easiest region to biopsy and feel with DRE What's the third zone called?

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Central zone; impervious to pathology. Like me.

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Point to the zones

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Transitional Zone Peripheral Zone

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What is the catalyst that believers testosterone into DTH?

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5 alpha reductase. In the prostate this catalyst changes over the testosterone emitted by the leydig cells of the testicles into DTH. Receptor are situated in the stroma. Testosterone receptors are in the epithelium.

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What's the sign of intense prostatitis? Neutrophils

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Granulomatous Prostatitis Key here is the nearness of mammoth cells and macrophages. Reaction to crack of intraluminal substance or TB/organisms.

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Benign Prostatic Hyperplasia Note the nodular appearance and the opening like state of the urethra because of pressure

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Prostatic intraepithelial neoplasia Precursor to obtrusive carcinoma of the prostate Intraductal injury

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Normal prostate Stained with high sub-atomic weight cytokeratin. Take note of the constant layer of recoloring around the organs

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Benign prostatic hyperplasia More stroma, more organs, more cell, more enlarged

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Prostatic intraepithelial neoplasia HMWC recolor: interferences in the basal cell layer. Forerunner sore to adenocarcinoma of the prostate.

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Prostate Carcinoma Most regularly in fringe zone Most frequently adenocarcinoma Firm yellow white knob on gross

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T/F: the prostate is vital for generation/richness False. The prostate secretes bacterialcidal fluid that enacts the sperm, yet is a bit much for sperm reasonability.

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Cystitis This is intense irritation

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Prostate adenocarcinoma Lots of little organs

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Prostate adenocarcinoma Grade 5: undifferentiated. Can't advise it's adeno. Melded masses of dangerous cells

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Common destinations of prostate CA metastases: Bone (blastic sores, not lytic sores) Lymph hubs Invasion is regularly by perineural intrusion

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Prostate CA Perineural attack

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Adenocarcinoma of the prostate Note that the harmful organs do not have the HMWK recolor… nonattendance of basal cell layer is terrible.

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Prostatic Abscess Look for this when you are diagnosing intense bacterial prostatitis. Vital to discover on the grounds that anti-microbials won't infiltrate the sore. Treatment for intense bacterial prostatitis is for the most part with Quinolones.

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Bladder Wall Image demonstrates the different layers Urothelium Lamina propria Muscularis propria

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Urothelium Note the shallow umbrella cells… enormous and wide…

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Horseshoe Kidney Congenital abnormality Does not bring on any practical issues Important for radiation and surgical medications…

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Renal Dysplasia Most regular reason for stomach mass in babies Undifferentiated tubules and conduits in cluster of undifferentiated mesenchyme Can now and again contain ligament and muscle Note the growths

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T/F: Adult polycystic sickness is autosomal predominant True. Puerile polycystic ailment is autosomal latent.

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Infant polycystic kidney illness Autosomal passive Cysts = Dilations of the gathering framework ¾ newborn children bite the dust in perinatal period Gross: extended however smooth kidneys, as opposed to the grown-up type of the malady, where the kidneys are developed yet contorted…

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Hydronephrosis and hydroureter Due to some hindrance distal to the kidney Obstruction can be inborn (stones, UT neoplasm) or outward (BPH, pregnancy)

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Clear Cell renal cell carcinoma Cells are loaded with glycogen Classic showing group of three: Flank torment Hematuria Abdominal mass Rare to have patients give these side effects…

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Adult polycystic renal sickness Bilateral Autosomal predominant Midlife renal disappointment Cysts scattered with typical kidney Big twisted kidneys

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Infant polycystic kidney infection Note how smooth the augmented kidney is

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This is connected with which sort of bladder tumor?

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Squamous cell CA Schistosomiasis Rare in US, regular around the world

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Seminoma Testicular germ cell neoplasm Note the lymphocytes and dangerous germ cells? What sort of tumor markers will seminomas have?

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AFP – and BHCG –

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Embryonal CA Big revolting cells Some corruption What sort of tumor markers?

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AFP + and BHCG –

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Yolk sac tumor This is a picture of the chacteristic sore called a schiller-duval body..tuft of harmful cells around a vessel what age assemble does this hit? Young men more youthful than 10 What tumor markers? AFP + and BHCG –

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Choriocarcinoma I figure some of these are synciciotrophoblasts and some are cytotrophoblasts What markers? AFP – and BHCG +++

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Teratoma Tissues from every one of the three germ cell layers Note the ligament and organs (GI tract cells)