Sub-atomic Displaying J-Term 08

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Figure out how to utilize computational projects like gaussian03, Unix, Linux, ... with different agonists uncovers sub-atomic determinants in charge of tying partiality. ...

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Sub-atomic Modeling J-Term 08 By: Laura Megorden

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Goals and Objectives Learn how to utilize computational projects like gaussian03, Unix, Linux, webMO, and webAMBER, and VMD Create a page that subtle elements my work in class and on my venture Create an examination venture that uses my insight on the computational projects Present my venture to the class

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QUESTION : What do these individuals have in like manner?

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Jose Canseco

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Marion Jones

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50 Cent & Timbaland

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Roger Clemens & Jason Giambi

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Barry Bonds & Mark McGuire

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Mary J. Blige & Wyclef Jean

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ANSWER: ANSWER: All of these Professional Athletes and Performers have been connected to steroid mishandle.

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Anabolic steroids A class of steroid hormones identified with testosterone Known to expand protein blend inside cells which brings about development of cell tissue, particularly in muscles. Have 2 properties: Androgenic: Responsible for control of "male" attributes Anabolic: Regulate anabolic procedures like amalgamation of protein in muscle, development of platelets, and the passionate and physical parts of sexual capacity

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Medicinal utilization of Steroids Used to invigorate bone development Stimulate craving Induce male adolescence Have been utilized to treat malignancy and AIDS Increase bulk and physical quality **This trademark makes them so appealing to competitors

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Risks and Side Effects Changes in cholesterol levels Acne High pulse Liver harm Changes of the left ventricle of the heart

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Testosterone is firmly identified with anabolic steroids. It is generally taken by guys since it is delivered actually by the testicles and flows through the blood following up on cells all through the body. It is transported inside bearer proteins in the blood. The transporter proteins then gradually discharge testosterone which can then sneak past cell films and into cells. When it is inside the cells it figures out how to get into the core and ties to the androgen receptor and changes the declaration of numerous qualities turning on the anabolic and androgenic capacities

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Testosterone Continued Testosterone is made well ordered by a procedure of accumulation of chemicals. 17-beta-hydroxysteroid dehydrogenase is the protein that plays out the last stride in changing over androstenedione into testosterone Androstenedione 19-carbon steroid hormone created in the adrenal organs and the gonads, that goes about as the transitional stride in the pathway that produces testosterone.

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Structures of Androstenedione and Testosterone Crystal structure of human estrogenic 17beta-hydroxysteroid dehydrogenase complex with androstanedione and NADP Crystal structure of human androgen receptor ligand restricting area in complex with testosterone

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My definitive objective for this venture is to look at the structures of Androstenedione and Testosterone utilizing an assortment of apparatuses including webMO, webAMBER, and VMD.

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Works Cited Pereira de Jesus-Tran, K. ,   Cote, P.- L. ,   Cantin, L. ,   Blanchet, J. ,   Labrie, F. ,   Breton, R. (2006) Comparison of precious stone structures of human androgen receptor ligand-restricting space complexed with different agonists uncovers sub-atomic determinants in charge of restricting liking. Protein Sci. 15: 987-999 Shi, R. ,   Lin, S.X. (2004) Cofactor hydrogen holding onto the protein primary chain is saved in the short chain dehydrogenase/reductase family and adds to nicotinamide introduction. J.Biol.Chem. 279: 16778-16785 D. H. Catlin (2006) Anabolic Steroids. Part 176 in the course reading: Endocrinology, altered by DeGroot and Jameson, Elsevier. C. Saudan, N. Baume, N. Robinson, L. Avois, P. Mangin and M. Saugy (2006) Testosterone and Doping Control. Diary of Sports Medicine 40(supplement 1), i21-i24.