Rett Syndrome Neurobiology of Disease
Slide 2Rett Syndrome second most regular hereditary reason for Mental Retardation Early advancement ordinary loss of dialect, psychological and engine capacities Single quality deformity: Mecp2 KO (Jaenisch, Bird) reiterates infection, as does forebrain neuron specific KO.
Slide 3http://www.ncbi.nlm.nih.gov/sickness/chr21-Y.html
Slide 4Zohgbi, 2003
Slide 5MeCP2 subdues quality expression
Slide 6Cre/lox framework http://www.bioteach.ubc.ca/MolecularBiology/TargetingYourDNAWithTheCreloxSystem/
Slide 7MeCP2 stifles quality expression But astoundingly little impact on quality expression recognized in microarray investigation of mouse KO Tudor et al. 2002
Slide 8Shabazian et al. 2002
Slide 9Luikenhuis, Giacometti, Beard, Jaenisch (2004) Fig 1.
Slide 10Luikenhuis, Giacometti, Beard, Jaenisch (2004) Fig 2.
Slide 11Luikenhuis, Giacometti, Beard, Jaenisch (2004) Fig 3.
Slide 12Luikenhuis, Giacometti, Beard, Jaenisch (2004) Fig 4.
Slide 13Dani et al. (2005) Fig 1.
Slide 14Dani et al. (2005) Fig 2.
Slide 15Fig 3. Dani et al. (2005)
Slide 16Fig 4. Dani et al. (2005)
Slide 17Fig 5. Dani et al. (2005)
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Asperger s Syndrome
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