Rett Syndrome

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Rett Disorder. Neurobiology of Sickness. Rett Disorder. second most basic hereditary reason for Mental Impediment Early improvement typical ? loss of dialect, psychological and engine capacities Single quality deformity: Mecp2 KO (Jaenisch, Feathered creature) summarizes ailment, as does forebrain neuron particular KO.

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Rett Syndrome Neurobiology of Disease

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Rett Syndrome second most regular hereditary reason for Mental Retardation Early advancement ordinary  loss of dialect, psychological and engine capacities Single quality deformity: Mecp2 KO (Jaenisch, Bird) reiterates infection, as does forebrain neuron specific KO.

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http://www.ncbi.nlm.nih.gov/sickness/chr21-Y.html

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Zohgbi, 2003

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MeCP2 subdues quality expression

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Cre/lox framework http://www.bioteach.ubc.ca/MolecularBiology/TargetingYourDNAWithTheCreloxSystem/

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MeCP2 stifles quality expression But astoundingly little impact on quality expression recognized in microarray investigation of mouse KO Tudor et al. 2002

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Shabazian et al. 2002

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Luikenhuis, Giacometti, Beard, Jaenisch (2004) Fig 1.

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Luikenhuis, Giacometti, Beard, Jaenisch (2004) Fig 2.

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Luikenhuis, Giacometti, Beard, Jaenisch (2004) Fig 3.

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Luikenhuis, Giacometti, Beard, Jaenisch (2004) Fig 4.

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Dani et al. (2005) Fig 1.

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Dani et al. (2005) Fig 2.

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Fig 3. Dani et al. (2005)

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Fig 4. Dani et al. (2005)

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Fig 5. Dani et al. (2005)

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