Restorative Eponyms: Intrigue and Infighting Behind the Names

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Medicinal Eponyms: Intrigue and Infighting Behind the Names Daniel A. Pollyea, MD University of Chicago March 7, 2006

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What is an Eponym?

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From the Greek eponymous Epi = "upon" Onyma = "name" Allow for shorthand strategy to pass on particular data Particularly prevalent in the medicinal field, albeit numerous other consistently cases Rudolf Diesel Adolphe Sax Jules L é otard

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Medical Definition "Name(s) of at least one people who concocted or depicted an anatomic structure, a grouping framework, an illness, a damage, a standard, a physical sign or an operation method" BUT… "One of the accompanying is generally valid for eponyms: The eponymized individual wasn't the principal describer; the eponymized individual didn't comprehend the disclosure; the eponym's present significance is not quite the same as that which was portrayed; the eponym has no authentic premise." –Mark M. Ravitch, MD

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Eponyms in the Medical Literature 1974 US National Institutes of Health meeting hung on the naming of ailments JAMA distributed an article vowing to drop the possessive "s" (Archer J. Encapsulations. JAMA 234:152, 1975) however diary editors throughout the years have been separated

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Types of Eponyms Named after male doctors (2,880 on Named after female doctors (101) First and last name Austin Flint Named after more than one individual Charcot-Marie-Tooth-Hoffman ailment Named after celebrated individuals with the illness Lou Gerhig Named after anecdotal characters Ulysses

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Case #1: Crohn's Disease Subacute constant enteritis including the terminal ileum and different parts of the GI tract ("lips to rear-end"), described by inconsistent, profound ulcers that may bring about fistulas, with noncaseating granulomas Symptoms incorporate fever, looseness of the bowels, cramping, stomach torment and weight reduction Distinguished from UC in light of the fact that irritation is transmural, and nearness of "skip sores"

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Colonic ulceration in Crohn's

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Our Story Begins at Mt. Sinai Hospital in NYC, in 1930…

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Granulomas of Crohn's were thought to be of an irresistible etiology:

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Leon Ginzburg, MD

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Case #2: Pickwickian Syndrome of hypoventilation and hypercapnia bringing about daytime lethargy, pneumonic hypertension and incidentally, polycythemia Cause: Extreme weight

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1837: Charles Dickens composed The Posthumous Papers of the Pickwick Club

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Literary Origin (and the current variant) "A most savage and startling thumping was heard at the entryway… The protest that introduced itself to the eyes of the surprised assistant was a kid a magnificently fat kid habited as a serving chap, standing upright on the tangle, with his eyes shut as though in rest. He had never observed such a fat kid, in or out of a voyaging parade; and this, combined with the smoothness and rest of his appearance, so altogether different from what was sensibly to have been normal in the inflictor of such a thump, destroyed him with ponder. "What's the matter?" asked the agent. The uncommon kid answered not a word; but rather he gestured once, and appeared, to the agent's creative energy, to wheeze weakly… He inhaled vigorously, however in every other regard was still." The assistant rehashed the question thrice, and getting no reply, arranged to close the entryway, when the kid all of a sudden opened his eyes, winked a few times, sniffled once, and raised his hand as though to rehash the thumping. "What the villain do you thump in that path for?" asked the assistant, indignantly. "Since ace said, I wasn't to leave off thumping till they opened the entryway, for dread I ought to go to rest," said the kid.

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119 Years Later… "Outrageous Obesity Associated with Alveolar Hypoventilation: A Pickwickian Syndrome" by CS Burwell, et al., 1956 Described a 51-year-old business official who stood 5'5" and weighed more than 260 lbs.

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Case #3: Brugada Syndrome Right package branch design with ST rise from V1-V3 Associated with sudden cardiovascular passing in youngsters without auxiliary coronary illness and a negative stretch test Often connected with syncope, VF/VT

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Evolution of the Syndrome 1953: Drs. Osher and Woff noticed the trademark EKG design, and thought of it as an ordinary variation 1980's: CDC in Atlanta noticed a high occurrence of youthful Thai outsiders passing on of sudden heart demise. In Thailand, this continuous condition was known as Lai Thai (demise amid rest). Later this populace would be found to have high frequencies of the transformation connected with Brugada.

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1986: Pedro Brugada treats a male Polish youngster with syncope whose sister kicked the bucket of sudden heart demise. With sibling Josep, gathered more instances of this trademark EKG and its relationship with sudden cardiovascular demise in youngsters

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1992: Brugada siblings, from Catalonia, Spain, depict the element 1998: Specific quality changes in the Na-particle channels observed to be in charge of the trademark depolarization seen on EKG and the frequencies of sudden passing with no auxiliary coronary illness.

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Francois Gigot de la Peyronie (1678-1747)

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Case #4: Peyronie's Disease In a treatise on ejaculatory disappointment in 1743, Peyronie depicted a patient with "rosary dabs" of scar tissue along the dorsum of his penis Resulted in a bend in the erect penis

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Due to a connective tissue issue of plaque arrangement in the corpora cavernosa Affects .3-3% of men 40-60 years of age Can bring about penile agony half of cases suddenly relapse Usually started by penile injury amid intercourse, bringing about plaque development

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Peyronie gets the eponym, yet… First portrayed in 1587 by Giulio Casare Aranzi, a Bolognese anatomist Thought to be discipline for inbreeding, since the Byzantinian Emperor Heracles, who took his niece for his significant other, was said to have built up a penile distortion that "made him urinate into his face"

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1942 survey article hypothesized "when an adolescent is dependent frequently to sessions of delayed ungratified sexual yearnings, his prostate, being in a consistent condition of engorgement, will create prostatic hypertrophy" and result in Peyronie's malady Also refered to "bone chilling" female accomplices, giving as proof small time whose condition determined after his better half turned out to be "more desirous."

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Treatment "If treatment of the plaque with iodides is unsuccessful… or if the condition advances… then the entire penis should immediately be cut away" William J. Walsham, MD London specialist, 1903 Vitamin E, different surgical strategies, rectifying props…

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Case #5: Barrett's Esophagus Change of the esophageal covering from squamous to columnar (which is observed in the stomach) Thought to be a confusion of serious GERD Risk calculate for esophageal tumor (metaplasia)

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Norman Barrett, an Australian specialist, was the first to perceive these progressions However, he trusted they happened in light of the fact that these patients had an intrinsically short throat, and the stomach had barged in into the mid-section to repay Dr. Jean-Louis Lortat-Jacob, a French specialist, found the variations from the norm around an indistinguishable time from Barrett, and he accurately estimated that it was an obtained sore However, his paper was composed in French. Barrett composed his in English. The rest is history.

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Eponyms Etiquette It is poor shape to name something after yourself Follow the lead of Fred Askin: Make a long name Described a "Little round blue cell tumor of the thoraco-aspiratory area." The following paper alluded to "little round blue cell tumor of the thoraco-pneumonic locale (Askin's illness) Now essentially known as Askin's sickness

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Tashima's Syndrome CK Tashima (JAMA 194:208;1965) recognized Tashima's Syndrome "A doctor's hunt down another sign, infection or disorder to join his name to."