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MULTI-CENTER INDICATOR INTERVENTION RESEARCH ON SURGICAL PHROPHYLAXIS IN 2 HOSPITALS IN PEOPLE'S REPUBLIC OF CHINA Wang Qing 1 , Wang Yuqin 2 , Edelisa D.Carandang 3 , Dennis Ross-degnan 4 , Tang Jingbo 5 1 Center for Drug Reevaluation of State Drug Administration, P.R.China 2 Xuanwu Hospital of the Capital University of Medical Sciences, P.R.China 3 Action Program on Essential Drugs, WHO, Geneva, Switzerland 4, Harvard Medical School and Harvard Pilgrim Health Care, Boston, USA 5. Liuhuaqiao Hospital, Guangzhou, P.R.China

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ABSTRACT OBJECTIVE Through the intercession and correlation investigation of balanced anti-infection agents use in perisurgical period, we need to investigate an arrangement of logical assessment and mediation techniques which are fit for China's circumstance, and advance the improvement of reasonable medication use in China. Techniques Selected two third level general doctor's facilities and isolated them into intercession doctor's facility and control healing facility. Offered mediation to the intercession doctor's facility from February 2001 to August 2001, and did the examination investigate on a similar time of inpatient surgical instances of thryroidectomy, mastectomy, cholescystectomy, and hysteromyomectomy +appendix from 2000 to 2002. Comes about The normal anti-infection agents use was chopped down from 740.20 RMB to 352.03 RMB (P<0.01) in intercession healing center from 2000 to 2001, yet did a reversal to 494.62 RMB in 2002. There was a wonderful change on the reasonability of anti-microbials use in intercession clinic amid the mediation approaches executed, however the circumstance did a reversal after the intercession halted. The discernment rates in intercession healing facility are from 22.88% to 80.33% and to 20.66%. In the mean time, there is no distinction on the levelheadedness of control doctor's facility. CONCLUTION: It is practicable and viable to execute the levelheaded medication utilize mediation in the exploration, and they assume dynamic parts on advancing securely, adequately and monetary anti-infection use in China. Te follow-up study in 2002 likewise demonstrated that the work for advancing discerning medication utilize is a long haul assignment. The mediation ought to go ahead to keep the prescriber's great practice.

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BACKGROUND INTRODUCTION From 2001 to 2002, the principal efficient multi-focus balanced medication utilize (RDU) investigate in China was done by Center for Drug Reevaluation of State Drug Administration and Xuanwu Hospital Group. The examination got the money related and specialized support from WHO/EDM. This anti-infection prophylaxis mediation study was the primary piece of this examination. Foundation In both the created and the creating scene, therapeutically improper, incapable, and monetarily wasteful utilization of pharmaceuticals ordinarily happens in human services offices. In China, self-drug, polypharmacy, abuse of anti-infection agents and infusions are anything but difficult to be watched. In 2001, a national pharmaceutical circumstance review in four urban communities of China was directed by MOH and SDA of China. The review was centered around the data of individuals' entrance to key medications and medication wellbeing, adequacy, quality and unwavering quality and also the best possible use of them. 26 clinics, 21 sedate outlets, and 4 tranquilize distribution centers were incorporated into the overview. The outcomes demonstrated that unreasonable medication use in these four urban communities is prevalent, particularly the rates of anti-toxin and infusion utilize are 47.82% and 35.13% separately. In the treatment of non-pneumonia- - intense respiratory tract contamination in outpatients among 26 healing centers, the rate of anti-toxins utilize is 83.5%, a ntipyretic/pain relieving 37.7%, c ough as well as cool medications 62.7% and different medications 48.8%. After level I evaluation, the best possible handlings are just 16.5% and the despicable ones are as high as 83.5%. After level II evaluation, the best possible handlings are 46.5% and the ill-advised ones are 53.5%.

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BACKGROUND Inappropriate anti-microbial utilize expands costs and the dangers of anti-toxin resistance. Around half of main 50 sedate uses in doctor's facilities in Chinese significant city between 1993-1995 were on anti-infection agents, yet just half of costs have a place with balanced utilize markers. As indicated by the review in the Outpatient Department of Beijing Children's Hospital from 1990 to 1993, more than 98% of the patients who were determined to have normal cool were given anti-toxins by doctors, and more than 33% of the patients had been taking anti-infection agents before going to the doctor's facility. Utilizing a delicate Staphylococcus aureus examine, it was found that 70% of blood tests and 43% of cerebrospinal liquid specimens from the patients with bacterial meningitis and pneumonia contained antibacterial movement. Microbes were recouped essentially less regularly from the specimens with antibacterial movement than from the individuals who did not from which anti-infection was not recuperated, both in blood (5.3% versus 12.5%) and in cerebrospinal liquid (2.5% versus 14.8%). Furthermore, some past studies in China had found a few issues in the way that anti-infection agents were utilized amid perisurgical period : off base sign for prophylactic utilize; determination of a wrong anti-toxin or measurement; start of anti-toxin treatment a few days before surgery without indication of contamination; and continuation of treatment for a mistaken time span, and so on. These studies show that anti-toxin manhandle is an extreme issue in China and that prudent utilization of anti-toxins is desperately required. In this mediation explore, we tried endeavors to create and execute concurred rules for antimicrobial prophylaxis in surgery with the point of advancing balanced anti-infection utilize, diminishing anti-toxin costs. It is regular that half of healing facility incomes from the offer of medications in China, which can prompt to doctors endorsing more prominent quantities of medications and more costly medications. Silly medication utilize has got increasingly consideration from the general population and therapeutic offices. The work of advancing reasonable medication utilize (PRDU) in China was started 20 years prior, yet the greater part of the inquires about are independently and no correlation, the system connected was not reliable. RDU has not been a vital pointer for wellbeing unit assessment now, furthermore it is still not the key segment of national medication approach. In this way, We anticipate investigating a goal and logical assessment and research technique to advance the work of RDU in China.

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MATERIALS AND METHOD All surgical inpatient instances of thryroidectomy, mastectomy, cholescystectomy, and hysteromyomectomy in addition to reference section from June 1 to July 7, 2000 and 2001in two healing facilities and a similar time of cases in 2002 of intercession doctor's facility were gathered in the study. The information gathering structure was figured before standard information accumulation. And all substance on the shape were recorded in the PC, including the data about patient and affirmation, data about surgery and anti-infection utilize, and so forth. Foxpro6.0 and SPSS 10.0 were utilized to do the examination. The prophylaxis rule was defined to give a structure to the mediation, and for the rule to have greatest impact, we actualized inside the intercession healing center efficiently utilizing an assortment of instructive and administrative methods.

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INTERVENTION Interventions were centered around advancing objective anti-toxin prophylaxis utilize and lessening anti-infection costs. 1.Education: Training, printed instructive materials and up close and personal instructive techniques are utilized to various instructive targets. ��  To specialists and drug specialists: *   The anti-microbial prophylaxis rule was defined and talked about by specialists and specialists from various bureaus of intercession healing center. The way toward requesting recommendations from clinical divisions was dealt with as an essential piece of rule advancement. * Several RDU workshops and classes were directed to present the RDU learning toward the starting and amid the exploration. * Printed RDU materials. For instance, "Why and what is the sound medication use?", "The circumstance of silly medication use on antibiotics", "The rule of anti-infection agents use", "Rational utilization of antibiotics", and so forth *   Several arrangements of reference books were scattered to each related division of mediation healing center. ② To chairmen of healing center The directors were moved and influenced by going to PRDU semiars and commonly of up close and personal reports. Their understanding, supporting and helping is one of the key components for the achievement of the exploration. 2. Administration: ��  The plan of the standard treatment rule ② Regular meeting of mediation healing facility. All individuals from the study group have gatherings no less than two times one month. Furthermore, for the center agents, there was no less than one short meeting one week. ③ Monitor in intercession clinic was designated to do the examination. Two screens in intercession clinic were named to do the day by day assessment. At whatever point the issue happened, the screen would answer to the chief of the office, and the executive of the division would talk about or speak with the specialist or drug specialist in the office to handle the issue.

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Hospital/Year Intervention Hospital Control Hospital 2000 2001 2002 2000 2001 Total cases 118 122 121 120 Male 17 15 19 22 16 Female 101 107 102 98 104 Average age 48.36 50.22 49.2 48.32 48.68 Thryroidectomy 38 41 36 29 32 Mastectomy 10 16 10 Cholescystectomy 34 32 33 34 32 Hysteromyomectomy + Appendix 36 39 36 39 Table 1 General data for mediation and control healing center

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Rationality Intervention Hospital Control Hospital 2000 2001 2002 2000 2001 Rational cases 37 (31.35%) 112 (91.8%)** 64 (52.88%) 0 Irrational cases 81 (68.64%) 10 (8.2%)** 57 (47.12%) 120 (100%) 120 (100%) Total 118 122 121 120 Incidence of post-surgical contamination 0 Table 2 Rationalit