General Intestinal Histology

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Slide 1

´╗┐General Intestinal Histology

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Activities of the Gastrointestinal Tract Motility Secretion Digestion Absorption

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Intestinal Autonomic Nervous System

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Parasympathetic Nervous System

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Vagovagal or Long reflex

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The Enteric Nervous System

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Peptide Secretion

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Criteria for GI Hormones a physiologic boost in one a player in the GI tract creates a reaction in another part the reaction must be autonomous of the sensory system the physiologic reaction can be copied with a "concentrate" from the jolt site the substance must be detached, sanitized, distinguished artificially, and combined

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Gastrin Stimulates gastric corrosive discharge and development of gastric oxyntic organ mucosa. Discharged from the gastric antrum and maybe the duodenum. Discharge is empowered by peptides, amino acids, gastric extension and incitement of the vagus.

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Structure of Human "little" Gastrin

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Cholecystokinin (CCK) Stimulates gallbladder withdrawal, pancreatic protein and bicarbonate emission, and development of the exocrine pancreas Inhibits gastric discharging Released from the duodenum and jejunum Release is invigorated by peptides, amino acids and >8C unsaturated fats, and to a lesser degree by corrosive

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Structure of porcine Cholecystokinin

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Secretin Stimulates pancreatic bicarbonate discharge, biliary bicarbonate emission, development of the exocrine pancreas, and pepsin discharge Inhibits gastric corrosive emission and the trophic impact of gastrin Secreted by the duodenum Secretion is empowered by corrosive and to a lesser degree fat

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Secretin Family of Peptides

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Gastric Inhibitory Peptide (GIP) Stimulates insulin discharge Inhibits gastric corrosive discharge Secreted by the duodenum and jejunum Secretion is actuated by glucose, amino acids and unsaturated fats

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Motilin Stimulates gastric and intestinal motility Released by the duodenum and jejunum Release is fortified by nerves, fat and corrosive

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Candidate Hormones Pancreatic polypeptide-a 36 amino corrosive peptide discharged from the pancreas in light of every one of the three nourishment stuffs Peptide YY-a 36 amino corrosive peptide discharged from the ileum and colon because of suppers, particularly fat Enteroglucagon-is available in the distal small digestive system and discharged into the circulatory system

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Paracrines Act on cells in the prompt region, not through the circulation system. Somatostatin Histamine

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Somatostain Inhibits gastrin discharge, arrival of other peptide hormones and gastric corrosive emission. Discharged from the GI mucosa and the pancreatic islets. Discharge is incited by corrosive. Discharge is restrained by vagal incitement.

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Histamine Stimulates gastric corrosive discharge. Discharged from oxyntic organ mucosa and enterochromaffin-like (ECL) cells. Discharged because of gastrin.

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Neurocrines Released from neurons by an activity potential, then diffuse over the synaptic parted to the objective tissue Vasoactive intestinal peptide (VIP) Bombesin or gastrin-discharging peptide (GRP) Enkephalins

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Vasoactive Intestinal Peptide Stimulates intestinal and pancreatic emission. Unwinds sphincters and gut roundabout smooth muscle by and large. Discharged by cells in the mucosa and smooth muscle of the GI tract.

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Bombesin or Gastrin-discharging peptide Stimulates gastrin discharge. Discharged by cells in the gastric mucosa.

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Enkephalins Stimulates smooth muscle withdrawal. Represses intestinal discharge. Discharged from cells in the GI mucosa and smooth muscle.

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Smooth Muscle Cells They are littler than skeletal muscle cells and long, restricted and axle molded. Cells that have a place with a package are practically coupled by crevice intersections. There are no sacromeres, in this way no striations. The proportion of thin to thick fibers is 15:1.

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Robert D. Specian, Ph.D.