Drug measurements

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Measurements reaction relationship. Relies on upon numerous components A medication ordinarily has one craved impact that causes an adjustment in an objective organ or structureIt will likewise have optional impacts in light of the fact that it will be consumed by different zones of the body. . Primary impacts and symptoms. Principle impact

Presentation Transcript

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Sedate dose

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Depends on numerous variables A medication more often than not has one fancied impact that causes an adjustment in an objective organ or structure It will likewise have optional impacts since it will be consumed by different ranges of the body Dose-reaction relationship

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Main impact – the impact you need the medication to have Side impacts – auxiliary impacts that could conceivably be alluring or accommodating Goal is to utilize a measurements of a medication that is compelling, however has negligible symptoms Main impacts and reactions

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Making dose choice Compare dose to the rate of individuals indicating diverse impacts ED 10 - powerful measurement where 10% of individuals show reaction of intrigue Example – doses of a medication used to build consideration (fundamental impact) additionally has 2 reactions Heart palpitations passing Dosage-reaction bend

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A measure of medication wellbeing The proportion of the dose at which half of patients would be required to pass on (LD 50 ) to the dose where half would demonstrate the coveted impact (ED 50 ) The bigger the proportion the more secure the medication The most secure medication is one that has the most particular activity. Few symptoms when it is given at remedial doses Therapeutic Index

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Infants take more time to metabolize most medications as a result of a juvenile liver Older grown-ups additionally don't metabolize sedates rapidly on the grounds that their framework less proficient Age as an element that impacts the medication reaction bend

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Gender particular medication reaction – guys and females physiologically extraordinary Psychological variables – desires most remarkably Other elements affecting medication reaction bend

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Metabolic resilience – long haul utilization of a medication can bring about incessant rise of compounds that metabolizes the medication Neuronal resistance – delayed utilization of a medication causes physical and concoction changes in neurons affected by the medication If the medication is a foe to a neurotransmitter (NT), the neurons may deliver a greater amount of the NT If an agonist, encourages the activity of the NT, the neuron could diminish the quantity of post-synaptic receptors or increment the arrival of chemicals History of Usage - Tolerance

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Behavioral resistance – the subject figures out how to beat the impacts of the medication – tranquilize levels stay high, however you figure out how to work typically "acting calm" Learned resistance – the body turns out to be traditionally adapted a medication is given over and over in a similar situation The body responds to the medication by creating catalysts to metabolize it Now nature flags the medication is coming and body responds before medication is taken Behavioral and scholarly resilience

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Drug collaboration – the impacts of taking 2 medications are not recently added substance; the reaction to 1 medication is enormously expanded or diminished by the organization of a moment Can be valuable or it can be an issue Example of a helpful connection: Drug A not viable at low measurements High doses aren't protected – the LD is low making the LD/ED little If sedate B builds the impact of medication A so it will be powerful at lower doses, that is great Drug Interactions on dosage reaction bend

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Interaction builds undesirable symptoms Mixing liquor with antidepressants, for example, prozac builds the danger of liver harm – a conceivable symptom of both Undesirable Interactions